Drug interactions
Fenfluramine + Flibanserin
Severity: Moderate
Fenfluramine and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs affect serotonergic signalling, so combined use could raise the risk of serotonin toxicity. Additive CNS effects such as sedation and dizziness may also occur.
What this interaction means in plain words
Fenfluramine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Flibanserin belongs to Genitourinary.
Why it happens
Additive serotonergic activity (flibanserin 5-HT1A agonism and 5-HT2A antagonism with fenfluramine serotonin release).
What to do
Monitor for agitation, tremor, hyperthermia, clonus and autonomic instability when starting or adjusting either drug. Counsel about sedation and dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Flibanserin?
MediHelp rates the interaction as moderate. Fenfluramine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs affect serotonergic signalling, so combined use could raise the risk of serotonin toxicity. Additive CNS effects such as sedation and dizziness may also occur.
How serious is the interaction between Fenfluramine and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, clonus and autonomic instability when starting or adjusting either drug. Counsel about sedation and dizziness.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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