Drug interactions
Fenfluramine + Granisetron
Severity: Minor
Fenfluramine and Granisetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine acts by releasing serotonin and stimulating serotonin receptors, so potent serotonin receptor antagonists could reduce its antiseizure effect. The clinical significance of 5-HT3 antagonists such as granisetron is uncertain, and the interaction is largely theoretical.
What this interaction means in plain words
Fenfluramine and Granisetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenfluramine belongs to Central Nervous System; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Possible pharmacodynamic antagonism of serotonergic activity that underlies fenfluramine's efficacy.
What to do
If granisetron is needed for short-term nausea control, monitor seizure frequency during and after use. No dose change is normally required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Granisetron?
MediHelp rates the interaction as minor. Fenfluramine and Granisetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenfluramine acts by releasing serotonin and stimulating serotonin receptors, so potent serotonin receptor antagonists could reduce its antiseizure effect. The clinical significance of 5-HT3 antagonists such as granisetron is uncertain, and the interaction is largely theoretical.
How serious is the interaction between Fenfluramine and Granisetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If granisetron is needed for short-term nausea control, monitor seizure frequency during and after use. No dose change is normally required.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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