Drug interactions
Fenfluramine + Haloperidol
Severity: Minor
Fenfluramine and Haloperidol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine is a serotonin-releasing agent used for seizures in Dravet and Lennox-Gastaut syndromes, and it can cause somnolence. Combined with haloperidol, additive CNS effects and a theoretical serotonergic or neuroleptic malignant syndrome risk exist, but clinical data are limited.
What this interaction means in plain words
Fenfluramine and Haloperidol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenfluramine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Overlapping CNS and serotonergic effects; no established pharmacokinetic mechanism.
What to do
Monitor for sedation, agitation, hyperthermia and rigidity when starting or adjusting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Haloperidol?
MediHelp rates the interaction as minor. Fenfluramine and Haloperidol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenfluramine is a serotonin-releasing agent used for seizures in Dravet and Lennox-Gastaut syndromes, and it can cause somnolence. Combined with haloperidol, additive CNS effects and a theoretical serotonergic or neuroleptic malignant syndrome risk exist, but clinical data are limited.
How serious is the interaction between Fenfluramine and Haloperidol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, agitation, hyperthermia and rigidity when starting or adjusting either drug.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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