Drug interactions
Fenfluramine + Hydromorphone
Severity: Moderate
Fenfluramine and Hydromorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine can cause somnolence and fatigue, rather than reducing sedation, and it increases serotonin release. Combined with hydromorphone, additive drowsiness is possible, and the net effect is not well characterized.
What this interaction means in plain words
Fenfluramine and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Hydromorphone belongs to Musculoskeletal.
Why it happens
Possible additive CNS effects; fenfluramine serotonergic activity may contribute, with no established pharmacokinetic interaction.
What to do
Monitor for excessive sedation and, rarely, serotonergic symptoms when starting or increasing either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Hydromorphone?
MediHelp rates the interaction as moderate. Fenfluramine and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine can cause somnolence and fatigue, rather than reducing sedation, and it increases serotonin release. Combined with hydromorphone, additive drowsiness is possible, and the net effect is not well characterized.
How serious is the interaction between Fenfluramine and Hydromorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and, rarely, serotonergic symptoms when starting or increasing either drug.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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