Drug interactions
Fenfluramine + Hydroxyzine
Severity: Moderate
Fenfluramine and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine can cause somnolence and lethargy in patients treated for seizures, which may add to the sedation of hydroxyzine. Fenfluramine also has serotonergic activity, but a specific clinically significant interaction with hydroxyzine is not well established.
What this interaction means in plain words
Fenfluramine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Probable additive CNS depressant effects; no specific mechanism has been established.
What to do
Monitor for excessive somnolence and counsel the patient or caregivers about it. Reduce the hydroxyzine dose if sedation interferes with function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Hydroxyzine?
MediHelp rates the interaction as moderate. Fenfluramine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine can cause somnolence and lethargy in patients treated for seizures, which may add to the sedation of hydroxyzine. Fenfluramine also has serotonergic activity, but a specific clinically significant interaction with hydroxyzine is not well established.
How serious is the interaction between Fenfluramine and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive somnolence and counsel the patient or caregivers about it. Reduce the hydroxyzine dose if sedation interferes with function.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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