Drug interactions
Fenfluramine + Lurasidone
Severity: Moderate
Fenfluramine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone is a potent 5-HT2A and 5-HT7 antagonist, whereas fenfluramine acts through serotonin release and receptor agonism. Lurasidone could therefore reduce the anticonvulsant benefit of fenfluramine, though clinical data are lacking.
What this interaction means in plain words
Fenfluramine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism of serotonergic receptor activity by lurasidone.
What to do
Monitor seizure frequency when the combination is used and reassess whether the antipsychotic is needed. Adjust therapy if seizure control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Lurasidone?
MediHelp rates the interaction as moderate. Fenfluramine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone is a potent 5-HT2A and 5-HT7 antagonist, whereas fenfluramine acts through serotonin release and receptor agonism. Lurasidone could therefore reduce the anticonvulsant benefit of fenfluramine, though clinical data are lacking.
How serious is the interaction between Fenfluramine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency when the combination is used and reassess whether the antipsychotic is needed. Adjust therapy if seizure control worsens.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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