Drug interactions
Fenfluramine + Midazolam
Severity: Moderate
Fenfluramine and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine is a CNS-active agent that can cause somnolence and sedation, so combining it with midazolam may add to CNS depression. Clinical data on this specific combination are limited.
What this interaction means in plain words
Fenfluramine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Probable additive CNS effects; no well-established pharmacokinetic mechanism.
What to do
Monitor for excessive sedation and impaired alertness when starting or adjusting either drug, and lower the midazolam dose if drowsiness is prominent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Midazolam?
MediHelp rates the interaction as moderate. Fenfluramine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine is a CNS-active agent that can cause somnolence and sedation, so combining it with midazolam may add to CNS depression. Clinical data on this specific combination are limited.
How serious is the interaction between Fenfluramine and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and impaired alertness when starting or adjusting either drug, and lower the midazolam dose if drowsiness is prominent.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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