Drug interactions
Fenfluramine + Nabilone
Severity: Moderate
Fenfluramine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine, used for seizures in Dravet and Lennox-Gastaut syndromes, can cause somnolence and also has serotonergic and appetite-suppressing effects. Combined with sedating nabilone, drowsiness may increase, though the net effect is unclear.
What this interaction means in plain words
Fenfluramine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Possible additive CNS effects; labeling for fenfluramine warns of additive CNS depression with other depressants.
What to do
Monitor for sedation and changes in alertness when starting or adjusting either drug. Advise caution with driving until response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Nabilone?
MediHelp rates the interaction as moderate. Fenfluramine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine, used for seizures in Dravet and Lennox-Gastaut syndromes, can cause somnolence and also has serotonergic and appetite-suppressing effects. Combined with sedating nabilone, drowsiness may increase, though the net effect is unclear.
How serious is the interaction between Fenfluramine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and changes in alertness when starting or adjusting either drug. Advise caution with driving until response is known.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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