Drug interactions
Fenfluramine + Perphenazine
Severity: Moderate
Fenfluramine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine is serotonergic and can cause somnolence, while perphenazine affects serotonin and dopamine receptors. The combination may alter sedation, and serotonin syndrome or arrhythmia is a theoretical concern.
What this interaction means in plain words
Fenfluramine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Overlapping serotonergic and CNS effects; the mechanism is not well established.
What to do
Monitor for serotonin toxicity, sedation and cardiac symptoms. Obtain ECG if other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Perphenazine?
MediHelp rates the interaction as moderate. Fenfluramine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine is serotonergic and can cause somnolence, while perphenazine affects serotonin and dopamine receptors. The combination may alter sedation, and serotonin syndrome or arrhythmia is a theoretical concern.
How serious is the interaction between Fenfluramine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity, sedation and cardiac symptoms. Obtain ECG if other QT-prolonging drugs are present.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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