Drug interactions
Fenofibrate + Fluvastatin
Severity: Moderate
Fenofibrate and Fluvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate with fluvastatin modestly raises the risk of myopathy and rhabdomyolysis, particularly with renal impairment. Fluvastatin is metabolized mainly by CYP2C9, so the concern is mostly pharmacodynamic.
What this interaction means in plain words
Fenofibrate and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenofibrate belongs to Cardiovascular; Fluvastatin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic myotoxicity.
What to do
Use the lowest effective doses and monitor renal function. Advise patients to report muscle symptoms and check CK if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Fenofibrate with Fluvastatin?
MediHelp rates the interaction as moderate. Fenofibrate and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenofibrate with fluvastatin modestly raises the risk of myopathy and rhabdomyolysis, particularly with renal impairment. Fluvastatin is metabolized mainly by CYP2C9, so the concern is mostly pharmacodynamic.
How serious is the interaction between Fenofibrate and Fluvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor renal function. Advise patients to report muscle symptoms and check CK if they occur.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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