Drug interactions
Fenofibrate + Gliclazide
Severity: Minor
Fenofibrate and Gliclazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate improves insulin sensitivity and can modestly increase glucose lowering with sulfonylureas, with a possible risk of hypoglycemia. Fenofibrate also inhibits CYP2C9 in vitro, which could slightly increase gliclazide exposure.
What this interaction means in plain words
Fenofibrate and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Gliclazide belongs to Endocrine.
Why it happens
Additive glucose lowering and possible weak CYP2C9 inhibition or protein-binding displacement.
What to do
Monitor blood glucose when fenofibrate is started, especially in patients with low albumin. Reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fenofibrate and Gliclazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Gliclazide
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Fenofibrate with Gliclazide?
MediHelp rates the interaction as minor. Fenofibrate and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate improves insulin sensitivity and can modestly increase glucose lowering with sulfonylureas, with a possible risk of hypoglycemia. Fenofibrate also inhibits CYP2C9 in vitro, which could slightly increase gliclazide exposure.
How serious is the interaction between Fenofibrate and Gliclazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fenofibrate is started, especially in patients with low albumin. Reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
