Drug interactions
Fenofibrate + Glipizide-metformin
Severity: Minor
Fenofibrate and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate may slightly enhance glucose lowering, and protein-binding displacement of glipizide is theoretically possible. Clinically significant hypoglycemia is uncommon.
What this interaction means in plain words
Fenofibrate and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
Possible protein-binding displacement and improved insulin sensitivity from PPAR-alpha activity.
What to do
Monitor blood glucose when starting fenofibrate, particularly in patients with low albumin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Fenofibrate with Glipizide-metformin?
MediHelp rates the interaction as minor. Fenofibrate and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate may slightly enhance glucose lowering, and protein-binding displacement of glipizide is theoretically possible. Clinically significant hypoglycemia is uncommon.
How serious is the interaction between Fenofibrate and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting fenofibrate, particularly in patients with low albumin.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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