Drug interactions
Fenofibrate + Glyburide-metformin
Severity: Minor
Fenofibrate and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate may modestly improve glycemia and is not generally associated with significant hypoglycemia with sulfonylureas. Any added glucose-lowering effect is small.
What this interaction means in plain words
Fenofibrate and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Possible protein-binding competition and PPAR-alpha-related improvements in insulin sensitivity.
What to do
No routine change is needed; monitor blood glucose when starting fenofibrate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Fenofibrate with Glyburide-metformin?
MediHelp rates the interaction as minor. Fenofibrate and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate may modestly improve glycemia and is not generally associated with significant hypoglycemia with sulfonylureas. Any added glucose-lowering effect is small.
How serious is the interaction between Fenofibrate and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor blood glucose when starting fenofibrate.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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