Drug interactions
Fenofibrate + Insulin degludec-liraglutide
Severity: Minor
Fenofibrate and Insulin degludec-liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates may improve glycemic parameters and insulin sensitivity in some patients, and this can add to the effect of insulin and liraglutide. Hypoglycemia is rarely reported, but the combination is common in diabetic dyslipidemia.
What this interaction means in plain words
Fenofibrate and Insulin degludec-liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Possible additive glucose lowering through improved insulin sensitivity (PPAR-alpha activation).
What to do
Monitor glucose when fenofibrate is started. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Fenofibrate with Insulin degludec-liraglutide?
MediHelp rates the interaction as minor. Fenofibrate and Insulin degludec-liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fibrates may improve glycemic parameters and insulin sensitivity in some patients, and this can add to the effect of insulin and liraglutide. Hypoglycemia is rarely reported, but the combination is common in diabetic dyslipidemia.
How serious is the interaction between Fenofibrate and Insulin degludec-liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when fenofibrate is started. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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