Drug interactions
Fenofibrate + Insulin degludec
Severity: Minor
Fenofibrate and Insulin degludec: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate may modestly improve insulin sensitivity, so insulin requirements can fall when it is added. This can lead to hypoglycemia if the insulin dose is not adjusted. The effect is generally small and manageable.
What this interaction means in plain words
Fenofibrate and Insulin degludec have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Additive glucose-lowering pharmacodynamic effect through improved insulin sensitivity; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping fenofibrate and reduce the insulin degludec dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Insulin degludec
Frequently asked questions
Can I take Fenofibrate with Insulin degludec?
MediHelp rates the interaction as minor. Fenofibrate and Insulin degludec have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate may modestly improve insulin sensitivity, so insulin requirements can fall when it is added. This can lead to hypoglycemia if the insulin dose is not adjusted. The effect is generally small and manageable.
How serious is the interaction between Fenofibrate and Insulin degludec?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fenofibrate and reduce the insulin degludec dose if hypoglycemia occurs.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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