Drug interactions
Fenofibrate + Istradefylline
Severity: Minor
Fenofibrate and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline can inhibit CYP3A4 at higher doses, but fenofibrate is not mainly cleared by this enzyme, so a clinically relevant increase is unlikely.
What this interaction means in plain words
Fenofibrate and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Theoretical dose-dependent CYP3A4 inhibition by istradefylline with limited relevance to fenofibrate.
What to do
No dose adjustment is needed. Routine monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Istradefylline
Frequently asked questions
Can I take Fenofibrate with Istradefylline?
MediHelp rates the interaction as minor. Fenofibrate and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline can inhibit CYP3A4 at higher doses, but fenofibrate is not mainly cleared by this enzyme, so a clinically relevant increase is unlikely.
How serious is the interaction between Fenofibrate and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Routine monitoring is sufficient.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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