Drug interactions
Fenofibrate + Mavacamten
Severity: Moderate
Fenofibrate and Mavacamten: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolized mainly by CYP2C19, and fenofibrate has shown weak CYP2C19 inhibition in vitro. Higher mavacamten exposure could increase the risk of reduced ejection fraction and heart failure. Clinical significance is uncertain.
What this interaction means in plain words
Fenofibrate and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenofibrate belongs to Cardiovascular; Mavacamten belongs to Cardiovascular.
Why it happens
Possible weak inhibition of CYP2C19-mediated mavacamten metabolism by fenofibrate.
What to do
Monitor left ventricular ejection fraction and clinical status when fenofibrate is started or stopped in patients on mavacamten. Follow the mavacamten labeling for echocardiographic monitoring and dose adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Fenofibrate with Mavacamten?
MediHelp rates the interaction as moderate. Fenofibrate and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten is metabolized mainly by CYP2C19, and fenofibrate has shown weak CYP2C19 inhibition in vitro. Higher mavacamten exposure could increase the risk of reduced ejection fraction and heart failure. Clinical significance is uncertain.
How serious is the interaction between Fenofibrate and Mavacamten?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction and clinical status when fenofibrate is started or stopped in patients on mavacamten. Follow the mavacamten labeling for echocardiographic monitoring and dose adjustment.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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