Drug interactions
Fenofibric acid + Warfarin
Severity: Moderate
Fenofibric acid and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibric acid can potentiate warfarin and raise INR, increasing bleeding risk. The effect is generally manageable with monitoring and dose adjustment.
What this interaction means in plain words
Fenofibric acid and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenofibric acid belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
Why it happens
Probable inhibition of CYP2C9 metabolism of warfarin, possibly with protein-binding displacement.
What to do
Monitor INR frequently when starting, changing or stopping fenofibric acid and lower the warfarin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Frequently asked questions
Can I take Fenofibric acid with Warfarin?
MediHelp rates the interaction as moderate. Fenofibric acid and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenofibric acid can potentiate warfarin and raise INR, increasing bleeding risk. The effect is generally manageable with monitoring and dose adjustment.
How serious is the interaction between Fenofibric acid and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR frequently when starting, changing or stopping fenofibric acid and lower the warfarin dose if needed.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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