Drug interactions
Fesoterodine + Givosiran
Severity: Minor
Fesoterodine and Givosiran: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran has been shown to moderately inhibit CYP2D6 and may increase exposure to the active metabolite of fesoterodine, which is partly cleared via CYP2D6. The clinical impact is likely modest because CYP3A4 provides an alternative clearance route.
What this interaction means in plain words
Fesoterodine and Givosiran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fesoterodine belongs to Genitourinary; Givosiran belongs to Miscellaneous.
Why it happens
Reduced CYP2D6 activity slows clearance of fesoterodine's active metabolite.
What to do
Monitor for anticholinergic effects such as dry mouth, constipation and urinary retention. Reduce the fesoterodine dose if these effects become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Fesoterodine with Givosiran?
MediHelp rates the interaction as minor. Fesoterodine and Givosiran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givosiran has been shown to moderately inhibit CYP2D6 and may increase exposure to the active metabolite of fesoterodine, which is partly cleared via CYP2D6. The clinical impact is likely modest because CYP3A4 provides an alternative clearance route.
How serious is the interaction between Fesoterodine and Givosiran?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as dry mouth, constipation and urinary retention. Reduce the fesoterodine dose if these effects become troublesome.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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