Drug interactions
Fexofenadine + Itraconazole
Severity: Minor
Fexofenadine and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole inhibits P-glycoprotein and raises fexofenadine plasma concentrations by increasing absorption and reducing elimination. The increase has not been linked to QT prolongation or notable toxicity.
What this interaction means in plain words
Fexofenadine and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Itraconazole belongs to Anti Fungals.
Why it happens
Inhibition of P-glycoprotein efflux of fexofenadine by itraconazole.
What to do
No dose adjustment is generally needed. Monitor for increased adverse effects, especially in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Fexofenadine with Itraconazole?
MediHelp rates the interaction as minor. Fexofenadine and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole inhibits P-glycoprotein and raises fexofenadine plasma concentrations by increasing absorption and reducing elimination. The increase has not been linked to QT prolongation or notable toxicity.
How serious is the interaction between Fexofenadine and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for increased adverse effects, especially in renal impairment.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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