Drug interactions
Fexofenadine + Lomitapide
Severity: Minor
Fexofenadine and Lomitapide: minor interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein and may increase fexofenadine plasma concentrations. The clinical effect is likely small because fexofenadine has a wide therapeutic margin.
What this interaction means in plain words
Fexofenadine and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Lomitapide belongs to Cardiovascular.
Why it happens
Lomitapide inhibits intestinal and renal P-gp efflux of fexofenadine.
What to do
Monitor for increased antihistamine adverse effects and consider a lower fexofenadine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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References
- Juxtapid - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Fexofenadine with Lomitapide?
MediHelp rates the interaction as minor. Fexofenadine and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide inhibits P-glycoprotein and may increase fexofenadine plasma concentrations. The clinical effect is likely small because fexofenadine has a wide therapeutic margin.
How serious is the interaction between Fexofenadine and Lomitapide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased antihistamine adverse effects and consider a lower fexofenadine dose if they occur.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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