Drug interactions
Fexofenadine + Lovastatin
Severity: Minor
Fexofenadine and Lovastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexofenadine is a P-glycoprotein substrate and lovastatin may weakly inhibit this transporter. Any rise in fexofenadine exposure is expected to be small and unlikely to cause clinically meaningful effects given its wide safety margin.
What this interaction means in plain words
Fexofenadine and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Lovastatin belongs to Cardiovascular.
Why it happens
Possible weak inhibition of P-glycoprotein-mediated efflux of fexofenadine by lovastatin.
What to do
No dose adjustment is needed; be aware of the theoretical effect if unexpected antihistamine adverse effects such as drowsiness or headache occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Fexofenadine with Lovastatin?
MediHelp rates the interaction as minor. Fexofenadine and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fexofenadine is a P-glycoprotein substrate and lovastatin may weakly inhibit this transporter. Any rise in fexofenadine exposure is expected to be small and unlikely to cause clinically meaningful effects given its wide safety margin.
How serious is the interaction between Fexofenadine and Lovastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; be aware of the theoretical effect if unexpected antihistamine adverse effects such as drowsiness or headache occur.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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