Drug interactions
Fexofenadine + Midazolam
Severity: Minor
Fexofenadine and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexofenadine is non-sedating at recommended doses, so no meaningful additive CNS depression with midazolam is expected.
What this interaction means in plain words
Fexofenadine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Midazolam belongs to Central Nervous System.
Why it happens
No established mechanism; fexofenadine does not significantly cross the blood-brain barrier.
What to do
No adjustment required; routine midazolam monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Frequently asked questions
Can I take Fexofenadine with Midazolam?
MediHelp rates the interaction as minor. Fexofenadine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fexofenadine is non-sedating at recommended doses, so no meaningful additive CNS depression with midazolam is expected.
How serious is the interaction between Fexofenadine and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment required; routine midazolam monitoring is sufficient.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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