Drug interactions
Fexofenadine + Tacrolimus
Severity: Minor
Fexofenadine and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can inhibit P-glycoprotein and might raise fexofenadine levels. Because fexofenadine is well tolerated at higher exposures, the effect is unlikely to matter clinically.
What this interaction means in plain words
Fexofenadine and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fexofenadine belongs to Respiratory; Tacrolimus belongs to Miscellaneous.
Why it happens
Inhibition of P-glycoprotein efflux of fexofenadine by tacrolimus.
What to do
No adjustment is needed; continue routine tacrolimus trough monitoring as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Fexofenadine with Tacrolimus?
MediHelp rates the interaction as minor. Fexofenadine and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tacrolimus can inhibit P-glycoprotein and might raise fexofenadine levels. Because fexofenadine is well tolerated at higher exposures, the effect is unlikely to matter clinically.
How serious is the interaction between Fexofenadine and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; continue routine tacrolimus trough monitoring as usual.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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