Drug interactions
Finasteride + Fluconazole
Severity: Minor
Finasteride and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is a moderate CYP3A4 inhibitor and may raise finasteride levels. Finasteride has a wide safety margin, so clinically important effects are not expected.
What this interaction means in plain words
Finasteride and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Finasteride belongs to Genitourinary; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated finasteride metabolism.
What to do
No dose adjustment is needed. Monitor for finasteride adverse effects during prolonged fluconazole use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Finasteride
- Finasteride + Levoketoconazole Moderate
- Finasteride + Nefazodone Moderate
- Finasteride + Rifampin Moderate
- Finasteride + St john's wort Moderate
- Amobarbital + Finasteride Minor
- Aprepitant + Finasteride Minor
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Frequently asked questions
Can I take Finasteride with Fluconazole?
MediHelp rates the interaction as minor. Finasteride and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole is a moderate CYP3A4 inhibitor and may raise finasteride levels. Finasteride has a wide safety margin, so clinically important effects are not expected.
How serious is the interaction between Finasteride and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for finasteride adverse effects during prolonged fluconazole use.
What other medicines interact with Finasteride?
MediHelp also lists interactions of Finasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Finasteride page.
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