Drug interactions
Finasteride + Itraconazole
Severity: Minor
Finasteride and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 inhibitor and can increase finasteride exposure. Because finasteride has a broad safety margin, the effect is usually not harmful.
What this interaction means in plain words
Finasteride and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Finasteride belongs to Genitourinary; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4, reducing finasteride clearance.
What to do
No routine dose change is needed. Watch for increased finasteride adverse effects during prolonged azole therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Finasteride
- Finasteride + Levoketoconazole Moderate
- Finasteride + Nefazodone Moderate
- Finasteride + Rifampin Moderate
- Finasteride + St john's wort Moderate
- Amobarbital + Finasteride Minor
- Aprepitant + Finasteride Minor
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Finasteride with Itraconazole?
MediHelp rates the interaction as minor. Finasteride and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole is a strong CYP3A4 inhibitor and can increase finasteride exposure. Because finasteride has a broad safety margin, the effect is usually not harmful.
How serious is the interaction between Finasteride and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for increased finasteride adverse effects during prolonged azole therapy.
What other medicines interact with Finasteride?
MediHelp also lists interactions of Finasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Finasteride page.
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