Drug interactions
Finerenone + Fluconazole
Severity: Moderate
Finerenone and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole, a moderate CYP3A4 inhibitor, raises finerenone exposure. Higher finerenone levels increase the risk of hyperkalemia and related renal effects, particularly in patients with diabetic kidney disease.
What this interaction means in plain words
Finerenone and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4-mediated metabolism of finerenone, increasing its plasma concentrations.
What to do
Check serum potassium and renal function when starting or changing either drug, and adjust the finerenone dose according to potassium results. Stop or hold finerenone if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Fluconazole?
MediHelp rates the interaction as moderate. Finerenone and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole, a moderate CYP3A4 inhibitor, raises finerenone exposure. Higher finerenone levels increase the risk of hyperkalemia and related renal effects, particularly in patients with diabetic kidney disease.
How serious is the interaction between Finerenone and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function when starting or changing either drug, and adjust the finerenone dose according to potassium results. Stop or hold finerenone if hyperkalemia develops.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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