Drug interactions
Finerenone + Fluvoxamine
Severity: Moderate
Finerenone and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine is a moderate CYP3A4 inhibitor and can raise finerenone concentrations, since finerenone is mainly cleared by CYP3A4. Higher exposure raises the risk of hyperkalemia and related renal effects.
What this interaction means in plain words
Finerenone and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Fluvoxamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of finerenone, increasing its plasma exposure.
What to do
Check serum potassium and renal function when starting the combination and after dose changes, and adjust finerenone per its labeling if potassium rises. Consider an alternative antidepressant that does not inhibit CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Fluvoxamine?
MediHelp rates the interaction as moderate. Finerenone and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine is a moderate CYP3A4 inhibitor and can raise finerenone concentrations, since finerenone is mainly cleared by CYP3A4. Higher exposure raises the risk of hyperkalemia and related renal effects.
How serious is the interaction between Finerenone and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function when starting the combination and after dose changes, and adjust finerenone per its labeling if potassium rises. Consider an alternative antidepressant that does not inhibit CYP3A4.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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