Drug interactions
Finerenone + Losartan
Severity: Moderate
Finerenone and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise serum potassium, so combined use increases hyperkalemia risk. A weak CYP3A4 effect of losartan on finerenone is minor by comparison.
What this interaction means in plain words
Finerenone and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Additive hyperkalemia from angiotensin receptor blockade and mineralocorticoid receptor antagonism.
What to do
Monitor serum potassium and renal function at initiation and after dose changes. Adjust or hold finerenone if potassium rises above labeled thresholds.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Losartan?
MediHelp rates the interaction as moderate. Finerenone and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs raise serum potassium, so combined use increases hyperkalemia risk. A weak CYP3A4 effect of losartan on finerenone is minor by comparison.
How serious is the interaction between Finerenone and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function at initiation and after dose changes. Adjust or hold finerenone if potassium rises above labeled thresholds.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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