Drug interactions
Finerenone + Midazolam
Severity: Minor
Finerenone and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a weak CYP3A4 inhibitor and may modestly raise finerenone exposure, increasing the risk of hyperkalemia. The effect is usually small, with single midazolam doses.
What this interaction means in plain words
Finerenone and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Finerenone belongs to Cardiovascular; Midazolam belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by midazolam reduces finerenone metabolism.
What to do
Monitor serum potassium when midazolam is used repeatedly with finerenone and adjust finerenone dosing if hyperkalemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Midazolam?
MediHelp rates the interaction as minor. Finerenone and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midazolam is a weak CYP3A4 inhibitor and may modestly raise finerenone exposure, increasing the risk of hyperkalemia. The effect is usually small, with single midazolam doses.
How serious is the interaction between Finerenone and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when midazolam is used repeatedly with finerenone and adjust finerenone dosing if hyperkalemia develops.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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