Drug interactions
Finerenone + Sirolimus
Severity: Moderate
Finerenone and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus is a weak CYP3A4 inhibitor and may modestly increase finerenone exposure. This raises the risk of hyperkalemia, which is especially relevant in kidney transplant recipients with reduced renal function.
What this interaction means in plain words
Finerenone and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Finerenone belongs to Cardiovascular; Sirolimus belongs to Miscellaneous.
Why it happens
Sirolimus weakly inhibits CYP3A4, reducing finerenone metabolism.
What to do
Monitor serum potassium and renal function at initiation and after dose changes, and adjust the finerenone dose per labeling if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Sirolimus?
MediHelp rates the interaction as moderate. Finerenone and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus is a weak CYP3A4 inhibitor and may modestly increase finerenone exposure. This raises the risk of hyperkalemia, which is especially relevant in kidney transplant recipients with reduced renal function.
How serious is the interaction between Finerenone and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function at initiation and after dose changes, and adjust the finerenone dose per labeling if potassium rises.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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