Drug interactions
Flecainide + Leuprolide
Severity: Moderate
Flecainide and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with leuprolide can prolong the QT interval. With flecainide, the proarrhythmic risk may be increased, particularly in patients with heart disease or electrolyte disturbance.
What this interaction means in plain words
Flecainide and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flecainide belongs to Cardiovascular; Leuprolide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and conduction; testosterone suppression is linked to QT prolongation.
What to do
Perform a baseline ECG and repeat periodically while on both drugs, and keep potassium and magnesium in range. Reconsider therapy if QTc or QRS lengthens markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Flecainide with Leuprolide?
MediHelp rates the interaction as moderate. Flecainide and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with leuprolide can prolong the QT interval. With flecainide, the proarrhythmic risk may be increased, particularly in patients with heart disease or electrolyte disturbance.
How serious is the interaction between Flecainide and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline ECG and repeat periodically while on both drugs, and keep potassium and magnesium in range. Reconsider therapy if QTc or QRS lengthens markedly.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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