Drug interactions
Flibanserin + Methylprednisolone
Severity: Minor
Flibanserin and Methylprednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin exposure is increased by CYP3A4 inhibitors, raising the risk of hypotension, syncope and sedation. Methylprednisolone is at most a weak, uncertain CYP3A4 modulator, so the effect is likely small, but caution applies when several weak inhibitors are combined.
What this interaction means in plain words
Flibanserin and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flibanserin belongs to Genitourinary; Methylprednisolone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 interaction affecting flibanserin clearance; not well established.
What to do
Counsel patients about dizziness and sedation, and avoid alcohol; review for additional CYP3A4 inhibitors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Methylprednisolone?
MediHelp rates the interaction as minor. Flibanserin and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Flibanserin exposure is increased by CYP3A4 inhibitors, raising the risk of hypotension, syncope and sedation. Methylprednisolone is at most a weak, uncertain CYP3A4 modulator, so the effect is likely small, but caution applies when several weak inhibitors are combined.
How serious is the interaction between Flibanserin and Methylprednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about dizziness and sedation, and avoid alcohol; review for additional CYP3A4 inhibitors.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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