Drug interactions
Flibanserin + Oxycodone
Severity: Moderate
Flibanserin and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxycodone and flibanserin both cause sedation and dizziness. Combined use may increase CNS depression and hypotension, and reduce the ability to drive or operate machinery.
What this interaction means in plain words
Flibanserin and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Warn the patient about additive sedation and avoid driving. Use the lowest effective oxycodone dose and monitor alertness and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Flibanserin with Oxycodone?
MediHelp rates the interaction as moderate. Flibanserin and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxycodone and flibanserin both cause sedation and dizziness. Combined use may increase CNS depression and hypotension, and reduce the ability to drive or operate machinery.
How serious is the interaction between Flibanserin and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about additive sedation and avoid driving. Use the lowest effective oxycodone dose and monitor alertness and blood pressure.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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