Drug interactions
Flibanserin + Palbociclib
Severity: Moderate
Flibanserin and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is a weak time-dependent CYP3A4 inhibitor. It could modestly raise flibanserin exposure, with a possible increase in dizziness and syncope.
What this interaction means in plain words
Flibanserin and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Palbociclib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by palbociclib.
What to do
Monitor for hypotension, syncope and sedation. Counsel the patient to avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Flibanserin with Palbociclib?
MediHelp rates the interaction as moderate. Flibanserin and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib is a weak time-dependent CYP3A4 inhibitor. It could modestly raise flibanserin exposure, with a possible increase in dizziness and syncope.
How serious is the interaction between Flibanserin and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hypotension, syncope and sedation. Counsel the patient to avoid alcohol.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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