Drug interactions
Flibanserin + Ranolazine
Severity: Moderate
Flibanserin and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine is a weak CYP3A4 inhibitor and may modestly increase flibanserin exposure. This could increase the risk of hypotension, syncope and sedation, particularly when combined with other CYP3A4 inhibitors.
What this interaction means in plain words
Flibanserin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Ranolazine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated flibanserin metabolism by ranolazine.
What to do
Monitor blood pressure and sedation, and avoid adding further CYP3A4 inhibitors. Counsel the patient about dizziness and fainting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Flibanserin with Ranolazine?
MediHelp rates the interaction as moderate. Flibanserin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine is a weak CYP3A4 inhibitor and may modestly increase flibanserin exposure. This could increase the risk of hypotension, syncope and sedation, particularly when combined with other CYP3A4 inhibitors.
How serious is the interaction between Flibanserin and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation, and avoid adding further CYP3A4 inhibitors. Counsel the patient about dizziness and fainting.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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