Drug interactions
Flibanserin + Repotrectinib
Severity: Moderate
Flibanserin and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin inhibits P-glycoprotein and could increase exposure to repotrectinib, a P-gp substrate. Higher repotrectinib levels could worsen neurologic toxicity.
What this interaction means in plain words
Flibanserin and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Repotrectinib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by flibanserin may raise repotrectinib levels.
What to do
Monitor for repotrectinib adverse effects such as dizziness and ataxia. Consider alternatives if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Flibanserin with Repotrectinib?
MediHelp rates the interaction as moderate. Flibanserin and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin inhibits P-glycoprotein and could increase exposure to repotrectinib, a P-gp substrate. Higher repotrectinib levels could worsen neurologic toxicity.
How serious is the interaction between Flibanserin and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for repotrectinib adverse effects such as dizziness and ataxia. Consider alternatives if toxicity occurs.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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