Drug interactions
Flibanserin + Risperidone
Severity: Moderate
Flibanserin and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation, orthostatic hypotension and syncope, so the combination may add to these effects. Theoretical serotonergic and dopamine-blocking overlap also exists, but documented cases are rare.
What this interaction means in plain words
Flibanserin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hypotensive effects, with possible pharmacodynamic overlap on serotonin and dopamine pathways.
What to do
Monitor for sedation, dizziness and low blood pressure. Warn the patient to report fever, muscle rigidity or marked agitation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Flibanserin with Risperidone?
MediHelp rates the interaction as moderate. Flibanserin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation, orthostatic hypotension and syncope, so the combination may add to these effects. Theoretical serotonergic and dopamine-blocking overlap also exists, but documented cases are rare.
How serious is the interaction between Flibanserin and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and low blood pressure. Warn the patient to report fever, muscle rigidity or marked agitation.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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