Drug interactions
Flibanserin + Rucaparib
Severity: Moderate
Flibanserin and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak-to-moderate inhibitor of CYP3A4 and CYP2C19, both involved in flibanserin metabolism. Flibanserin concentrations may rise, increasing hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Rucaparib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and CYP2C19 metabolism of flibanserin by rucaparib.
What to do
Monitor for dizziness, hypotension and sedation, and advise caution with driving; consider flibanserin dose review if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Flibanserin with Rucaparib?
MediHelp rates the interaction as moderate. Flibanserin and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a weak-to-moderate inhibitor of CYP3A4 and CYP2C19, both involved in flibanserin metabolism. Flibanserin concentrations may rise, increasing hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, hypotension and sedation, and advise caution with driving; consider flibanserin dose review if symptoms occur.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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