Drug interactions
Flibanserin + Tramadol
Severity: Moderate
Flibanserin and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tramadol is an opioid with sedative effects, and combined use with flibanserin may increase drowsiness, dizziness and impaired performance. Tramadol is also a CYP2D6 substrate and may lower seizure threshold, so tolerability should be watched.
What this interaction means in plain words
Flibanserin and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Tramadol belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Counsel on additive sedation and avoid driving. Use the lowest effective tramadol dose and monitor alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Flibanserin with Tramadol?
MediHelp rates the interaction as moderate. Flibanserin and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tramadol is an opioid with sedative effects, and combined use with flibanserin may increase drowsiness, dizziness and impaired performance. Tramadol is also a CYP2D6 substrate and may lower seizure threshold, so tolerability should be watched.
How serious is the interaction between Flibanserin and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive sedation and avoid driving. Use the lowest effective tramadol dose and monitor alertness.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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