Drug interactions
Flibanserin + Trazodone
Severity: Moderate
Flibanserin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, hypotension and syncope, and trazodone is also serotonergic, so effects may add up. Trazodone is not a significant CYP3A4 inhibitor.
What this interaction means in plain words
Flibanserin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depressant, hypotensive and serotonergic effects.
What to do
Monitor for sedation, orthostatic hypotension and syncope. Advise the patient to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Flibanserin with Trazodone?
MediHelp rates the interaction as moderate. Flibanserin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, hypotension and syncope, and trazodone is also serotonergic, so effects may add up. Trazodone is not a significant CYP3A4 inhibitor.
How serious is the interaction between Flibanserin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and syncope. Advise the patient to avoid driving until the response is known.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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