Drug interactions
Flibanserin + Triclabendazole
Severity: Moderate
Flibanserin and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole inhibits CYP2C19, which contributes to flibanserin metabolism, and may raise flibanserin levels. This may increase hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Triclabendazole belongs to Anti Parasitic.
Why it happens
Inhibition of CYP2C19 metabolism of flibanserin by triclabendazole.
What to do
Monitor for dizziness, sedation and hypotension during the short triclabendazole course; consider holding flibanserin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Flibanserin with Triclabendazole?
MediHelp rates the interaction as moderate. Flibanserin and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclabendazole inhibits CYP2C19, which contributes to flibanserin metabolism, and may raise flibanserin levels. This may increase hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, sedation and hypotension during the short triclabendazole course; consider holding flibanserin.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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