Drug interactions
Fluconazole + Gemifloxacin
Severity: Major
Fluconazole and Gemifloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lengthen the QTc interval, and fluconazole is also a CYP3A4 and CYP2C9 inhibitor that can raise exposure to other QT-active drugs. Together they increase the risk of torsades de pointes, especially with electrolyte disturbance or heart disease.
What this interaction means in plain words
Fluconazole and Gemifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade.
What to do
Prefer a non-QT-prolonging antibiotic or antifungal. If combined, check ECG, potassium and magnesium at baseline and during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Gemifloxacin?
MediHelp rates the interaction as major. Fluconazole and Gemifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can lengthen the QTc interval, and fluconazole is also a CYP3A4 and CYP2C9 inhibitor that can raise exposure to other QT-active drugs. Together they increase the risk of torsades de pointes, especially with electrolyte disturbance or heart disease.
How serious is the interaction between Fluconazole and Gemifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-QT-prolonging antibiotic or antifungal. If combined, check ECG, potassium and magnesium at baseline and during therapy.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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