Drug interactions
Fluconazole + Granisetron
Severity: Moderate
Fluconazole and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is associated with QT prolongation and torsades, mainly at higher doses or with other risk factors. Combined with granisetron the QT effect may be additive.
What this interaction means in plain words
Fluconazole and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation; fluconazole also inhibits CYP3A4, which may raise granisetron concentrations.
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Monitor the QTc, particularly with high fluconazole doses or additional QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Granisetron?
MediHelp rates the interaction as moderate. Fluconazole and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole is associated with QT prolongation and torsades, mainly at higher doses or with other risk factors. Combined with granisetron the QT effect may be additive.
How serious is the interaction between Fluconazole and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Monitor the QTc, particularly with high fluconazole doses or additional QT-prolonging drugs.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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