Drug interactions
Fluconazole + Indacaterol-glycopyrronium
Severity: Moderate
Fluconazole and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can prolong the QT interval, and indacaterol may add modest repolarization effects. Fluconazole is also a CYP3A4 inhibitor that may increase indacaterol exposure modestly. The combined risk of arrhythmia is mainly relevant with high fluconazole doses or other risk factors.
What this interaction means in plain words
Fluconazole and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive QT effects; CYP3A4 inhibition may raise indacaterol exposure.
What to do
Check ECG and electrolytes in patients with cardiac risk factors or on other QT-prolonging drugs. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Fluconazole and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can prolong the QT interval, and indacaterol may add modest repolarization effects. Fluconazole is also a CYP3A4 inhibitor that may increase indacaterol exposure modestly. The combined risk of arrhythmia is mainly relevant with high fluconazole doses or other risk factors.
How serious is the interaction between Fluconazole and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with cardiac risk factors or on other QT-prolonging drugs. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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