Drug interactions
Fluconazole + Ivacaftor
Severity: Moderate
Fluconazole and Ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole increases ivacaftor exposure, which may increase adverse effects such as transaminase elevation. Labeling calls for a reduced ivacaftor dose with moderate CYP3A inhibitors.
What this interaction means in plain words
Fluconazole and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Ivacaftor belongs to Miscellaneous.
Why it happens
Fluconazole inhibits CYP3A4-mediated ivacaftor metabolism.
What to do
Reduce ivacaftor to the dosing regimen stated in the product label for moderate CYP3A inhibitors, for example once daily or alternate-day dosing. Monitor liver enzymes and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Fluconazole with Ivacaftor?
MediHelp rates the interaction as moderate. Fluconazole and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole increases ivacaftor exposure, which may increase adverse effects such as transaminase elevation. Labeling calls for a reduced ivacaftor dose with moderate CYP3A inhibitors.
How serious is the interaction between Fluconazole and Ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce ivacaftor to the dosing regimen stated in the product label for moderate CYP3A inhibitors, for example once daily or alternate-day dosing. Monitor liver enzymes and tolerability.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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