Drug interactions
Fluconazole + Liposomal doxorubicin
Severity: Moderate
Fluconazole and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is a moderate CYP3A4 inhibitor and may modestly raise doxorubicin exposure. Increased myelosuppression or mucositis is possible, though CYP3A4 is a minor route for doxorubicin.
What this interaction means in plain words
Fluconazole and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Liposomal doxorubicin belongs to Oncology.
Why it happens
CYP3A4 inhibition by fluconazole, which may reduce doxorubicin clearance.
What to do
Monitor blood counts and mucositis. Reduce the doxorubicin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Fluconazole and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole is a moderate CYP3A4 inhibitor and may modestly raise doxorubicin exposure. Increased myelosuppression or mucositis is possible, though CYP3A4 is a minor route for doxorubicin.
How serious is the interaction between Fluconazole and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and mucositis. Reduce the doxorubicin dose if toxicity develops.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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