Drug interactions
Fluconazole + Losartan
Severity: Moderate
Fluconazole and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan is converted to its more potent active metabolite E-3174 mainly by CYP2C9 (with CYP3A4). Fluconazole inhibits these enzymes, so conversion may fall and the antihypertensive effect may be reduced in some patients.
What this interaction means in plain words
Fluconazole and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Losartan belongs to Cardiovascular.
Why it happens
Fluconazole inhibits CYP2C9 and CYP3A4, reducing conversion of losartan to E-3174.
What to do
Monitor blood pressure when fluconazole is started or stopped. Increase the losartan dose or switch to another ARB if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Fluconazole with Losartan?
MediHelp rates the interaction as moderate. Fluconazole and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Losartan is converted to its more potent active metabolite E-3174 mainly by CYP2C9 (with CYP3A4). Fluconazole inhibits these enzymes, so conversion may fall and the antihypertensive effect may be reduced in some patients.
How serious is the interaction between Fluconazole and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when fluconazole is started or stopped. Increase the losartan dose or switch to another ARB if control is lost.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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