Drug interactions
Fluconazole + Lurasidone
Severity: Moderate
Fluconazole and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is a moderate CYP3A4 inhibitor and increases lurasidone exposure, raising the risk of akathisia, sedation and other adverse effects. Lurasidone labeling advises dose limits with moderate inhibitors.
What this interaction means in plain words
Fluconazole and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Lurasidone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by fluconazole reduces lurasidone clearance.
What to do
Start lurasidone at a reduced dose of 20 mg daily and keep the maximum at 80 mg daily during fluconazole use. Monitor for extrapyramidal symptoms and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Fluconazole with Lurasidone?
MediHelp rates the interaction as moderate. Fluconazole and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole is a moderate CYP3A4 inhibitor and increases lurasidone exposure, raising the risk of akathisia, sedation and other adverse effects. Lurasidone labeling advises dose limits with moderate inhibitors.
How serious is the interaction between Fluconazole and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start lurasidone at a reduced dose of 20 mg daily and keep the maximum at 80 mg daily during fluconazole use. Monitor for extrapyramidal symptoms and sedation.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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