Drug interactions
Fluconazole + Macimorelin
Severity: Major
Fluconazole and Macimorelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so giving them together may add to the risk of torsades de pointes. Macimorelin is used as a diagnostic test, so the exposure window is short but the arrhythmic risk still applies.
What this interaction means in plain words
Fluconazole and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Macimorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation; fluconazole may also modestly raise macimorelin exposure through CYP3A4 inhibition.
What to do
Avoid combining where possible; if testing is needed, consider deferring the macimorelin test until fluconazole has been stopped and cleared (several days given its long half-life). Correct potassium and magnesium and obtain an ECG if the combination cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Fluconazole with Macimorelin?
MediHelp rates the interaction as major. Fluconazole and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QT interval, so giving them together may add to the risk of torsades de pointes. Macimorelin is used as a diagnostic test, so the exposure window is short but the arrhythmic risk still applies.
How serious is the interaction between Fluconazole and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if testing is needed, consider deferring the macimorelin test until fluconazole has been stopped and cleared (several days given its long half-life). Correct potassium and magnesium and obtain an ECG if the combination cannot be avoided.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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